News

Under-exploited plants offer untold medical and economic promise



A recent article in Nature by Ameenah Gurib Fakim, President of Mauritius and former Professor of Organic Chemistry, about the abundance of commercially available drugs that have their origins in plants. "Artemisinin, ginkgolides, quinine, reserpine, scopolamine, paclitaxel. What do these molecules have in common? They are all extracted from plants and transformed into useful drugs, treating conditions including malaria, nausea, cancer and high blood pressure. Almost 60% of commercially available drugs are based on molecules derived from natural sources. China and India have dedicat...
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AKL and APPA in the Press



Recently there have been various press reports on AKL's collaboration with Liverpool University on the clinical development of APPA. There has been coverage in both industry and mainstream press with Prof Rob Moots and Prof Steven Edwards being quoted extensively.     Pharma Times: Liverpool Uni leads clinical trial of promising osteoarthritis drug Drug Development Technology: Liverpool and AKL collaborate to evaluate APPA for osteoarthritis Daily Express: New treatment hailed as a 'new dawn' for arthritis sufferers Daily Mail: From Peonies to ease arthritic knees to...
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Liverpool University Press Release



Clinical trial for new innovative Osteoarthritis drug The University of Liverpool, in partnership with AKL Research and Development Ltd, is to lead on a clinical trial to test a potential new drug treatment for osteoarthritis. Osteoarthritis (OA) is the most common type of arthritis in the UK, affecting more than eight million people*, and is the leading cause of joint pain and stiffness in older people. As part of their research and development programme, AKL identifies promising phytochemicals, found in natural products, which are capable of being synthesized. Trials have identif...
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Summary of Effects of APPA on Neutrophils



AKL, in collaboration with the University of Liverpool, were accepted for a presentation at the 2016 OARSI (Osteoarthritis Research Society International) Congress Summary of Effects of APPA on Human Neutrophils Function APPA is a synergistic combination of 2 synthetic anti-inflammatory molecules. APPA has shown efficacy in several animal models of osteoarthritis, decreasing pain and meniscal cartilage damage. Its efficacy is thought to be due to the effects of the constituent components on various levels of regulation of the transcription factor, NF-κB but as we show here also has eff...
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