News

APPA has completed required preclinical studies



We believe APPA is now ready to apply for regulatory approval to start formal human trials now that required preclinical toxicology studies have been completed. There is a considerable body of evidence behind the efficacy, safety, tolerability and mode of action of APPA. Consistent with data in the public domain, the studies undertaken indicate that the toxicity potential of orally administered APPA is low. In vitro genotoxicity panel with ...
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New Family Link to Osteoarthritis



Brothers and sisters of osteoarthritis patients are twice as likely to develop the condition themselves, according to researchers in the East Midlands. The study, carried out at Nottingham’s City Hospital, also discovered that men were more likely to inherit the disease than women. Osteoarthritis is a painful condition causing inflammation and loss of cartilage, most commonly in the knee. Almost 500 patients with osteoarthritis took part in the...
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Paracetamol ‘useless’ in treating osteoarthritis pain



"Paracetamol is next to useless at alleviating arthritic pain," The Times reports. A comprehensive review of existing data suggests paracetamol should not be used in cases of osteoarthritis as there are far more effective treatments available. Osteoarthritis is now the leading cause of joint pain and stiffness in older people. The review showed that paracetamol, at any dose, had a very low chance of improving pain linked to osteoarthritis ...
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BMJ: Painkillers linked to increased risk of heart failure



Common painkillers such as ibuprofen used by millions of people in the UK are linked to an increased risk of heart failure, experts have said. Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) could increase the risk of being admitted to hospital. Previous studies have linked the drugs to abnormal heart rhythm – which can cause heart failure – and an increased risk of heart attack and stroke if taken regularly. The drug...
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Is there evidence that glucosamine improves things?



In collaboration with Prof Phil Conaghan of the University of Leeds, a world expert on joint pain, ‘Trust Me, I’m a Doctor’ recruited 80 people with painful knees. Phil and his team assessed their joints and asked them to rate their pain levels, and then 40 of them were given a "supplement pill" to take daily and the other 40 were given daily exercises. After two months, we asked them to rate their pain again. And the results were very tell...
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